July

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A significant family history of colorectal cancer may be related to a hereditary syndrome, such as Lynch syndrome, or a familial susceptibility. Hereditary colorectal cancer is associated with a germline pathogenic variant in a hereditary cancer gene and accounts for 5% to 10% of all colorectal cancers. Familial colorectal cancer encompasses a heterogeneous group who may have an increased colorectal cancer risk due to multifactorial genetic and shared environmental risk factors.

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