A BC research team has identified a set of molecular markers that can help determine whether individuals with oral precancerous lesions are at high risk of having those lesions progress to oral cancer.
The findings were published in Cancer Prevention Research and represent the only large-scale population study with long-term follow-up.
The study, led by Dr Miriam Rosin, director of the BC Cancer Agency’s BC Oral Cancer Prevention Program, validated the “loss of heterozygosity” analysis the team first discovered 10 years ago. This analysis successfully identified a change in the DNA of genes in specific chromosomes that have been shown to be highly predictive of the development of oral cancer.
Study findings show that patients with oral lesions can be grouped according to risk level, that two out of every three high-risk patients progressed to cancer, and that follow-up and treatment could be tailored to a patient’s risk level.
The study can be viewed online at http://cancerpreventionresearch.aacrjournals.org/.
Above is the information needed to cite this article in your paper or presentation. The International Committee
of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally
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Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.
About the ICMJE and citation styles
The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.
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For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org