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Clinical Articles / BY: Benjamin C.L. Lai, MD, MSc April 2001
... 50 years as the average age of the population increases.[ 1 ] PD is a slowly progressive neurodegenerative disorder ... the crude annual incidence rates of PD ranged from 1.5 per 100,000 population in China in 1986 to 14.8 in ... men than in women in most studies, usually ranging from a 1.2:1 ratio up to a 1.5:1 ratio. Ethnic distribution The ...
Clinical Articles / BY: Doris J. Doudet, PhD April 2001
... (FDOPA), is routinely used. First reported in 1983,[ 1 ] FDOPA uptake and storage (as fluoro-dopamine) in the ... the more caudal putamen most severely affected  Figure 1 .[ 5 ] Most often, Parkinson-plus syndromes such as ... demonstrated in neurologically normal patients exposed to 1-methyl-4-phenyl-1, 2,3,6 tetrahydropyridine (MPTP, a ...
Clinical Articles / BY: Edith McGeer, PhD April 2001
... disease (AD), where it has been extensively studied,[ 1,2 ] but there is also evidence suggesting that a local ... protein. Once activated, the complement cascade  Figure 1  produces anaphylatoxins that promote further ... such as tumor necrosis factor-alpha, interleukin-1, and interleukin-6, amplify and sustain inflammation and ...
Clinical Articles / BY: Donald B. Calne, OC, DM April 2001
... younger age than those who do not have a family history.[ 1 ] The many discoveries generated through the techniques of ...
Clinical Articles / BY: Donald B. Calne, OC, DM April 2001
Clinical Articles / BY: Ian R.A. Mackenzie, MD, FRCPC April 2001
... disease (PD) and the appropriateness of the terminology.[ 1 ] Traditionally, PD has been viewed as a specific entity in ... from the substantia nigra and locus ceruleus  Figure 1 . The caudate, putamen, globus pallidus, thalamus, and ... this indicates that Lewy bodies are not disease specific.[ 1 ] Pale bodies Pale bodies are ill-defined rounded areas of ...
Editorials / BY: James A. Wilson, MD April 2001
... party and I came to a fairly quick agreement and as of 1 January 2001 I started a sabbatical for 6 to 12 months. ...
Letters / BY: Lorna Sent, MD April 2001
... in BC (two to four times higher in BCCA study 1993).[ 1 ] The study concludes that the cervical cancer screening ...
Clinical Articles / BY: T.A. Hurwitz, MBChB, MRCP, FRCPC May 2001
... of uniform criteria for diagnosing depression. Cummings [1]  reviewed nine studies conducted between 1987 and 1990 ... even though verbalized suicidal ideation is not uncommon. [1]  In the Vancouver Hospital Movement Disorder Clinic ...
Clinical Articles / BY: Chong S. Lee, MD, FRCPC May 2001
... accompanies the development of sudden "on-off" responses. [1]  The threshold dose of levodopa for dyskinesia decreases ... observations were made in primates with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesions. [4]  In contrast, ...