... others only partially or not at all, and still others may experience undesirable, even fatal, side effects. The ... 2022[ 6 ] (2936 in Canada),[ 7 ] with a 23% increase from 2009 to 2018, and short-term survival has improved modestly. ... Opioid use disorder is a long-standing social and medical issue that has reached epidemic proportions in recent years, ...