... amplified by favorable results in recent large trials.[ 7 , 8 ] In the EPCAT II trial, a multicentre double-blinded ... vein thrombosis, pulmonary embolism, and bleeding events.[ 7 ] In the PREVENT CLOT trial, a large open-label randomized ... (2.5%), diabetes (8.3%), and a previous history of VTE (0.7%) were reported as comorbidities; the orthopaedic trauma ...