Teenage girls needed for Canadian HPV study

Canadian researchers are seeking 8666 teenage girls from across the country for a new national study that will determine whether two or three doses of the vaccine Gardasil provide similar protection against human papillomavirus (HPV). 

If study results show that two doses are effective, this would mean fewer needles for girls receiving the vaccine as well as cost savings for the health care system. While earlier studies have shown that two doses of Q-HPV vaccine are as protective as three doses for up to 36 months, the new study aims to prove that two doses remain effective in the long term.

The study, which will last up to 10 years, is seeking girls born between 1997 and 2000 from five centres across Canada to participate. The Vaccine Evaluation Centre at the Child & Family Research Institute at BC Children’s Hospital is recruiting 3609 participants from BC.

Girls participating in the study will complete an annual survey designed to address risk factors for getting HPV disease. Beginning in the year that they turn 15 and continuing for five consecutive years, girls will self-collect vaginal swabs and send them to the study lab, which will test for HPV and determine whether the number of doses received to date have offered adequate protection. There are also two optional blood samples that will be tested for levels of immune protection against HPV.

The study is designed to assess risk for HPV disease, HPV prevalence, and the levels of protection provided by two doses compared to three doses of the vaccine. It aims to answer these questions:

•    Are two doses of HPV vaccine good enough to continue to provide protection?
•    What level of HPV disease is present in the vaccinated population?
•    Is there a difference between the groups that have had two versus three doses of HPV vaccine?

For more information on the study, visit www.questhpvstudy.ca or call 604 875-2000 ext. 6501, toll free 1 866-502-2424.

. Teenage girls needed for Canadian HPV study. BCMJ, Vol. 55, No. 1, January, February, 2013, Page(s) 16 - News.

Above is the information needed to cite this article in your paper or presentation. The International Committee of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

About the ICMJE and citation styles

The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.

An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.

BCMJ standard citation style is a slight modification of the ICMJE/NLM style, as follows:

  • Only the first three authors are listed, followed by "et al."
  • There is no period after the journal name.
  • Page numbers are not abbreviated.

For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org

BCMJ Guidelines for Authors

Leave a Reply