New weapon for hard-to-treat bacterial infections

Issue: BCMJ, vol. 58, No. 9, November 2016, Page 524 News

Researchers at the University of British Columbia have successfully prevented drug-resistant bacteria from forming abscesses using a peptide, which worked by disrupting the bacteria’s stress response. Abscesses are responsible for 3.2 million emergency room visits every year in the United States, and standard treatment for abscesses involves cutting out the infected tissue or draining it.

Senior author Bob Hancock, a professor in UBC’s Department of Microbiology, clarified that the peptide offers a new strategy because its mechanism is completely different from every known antibiotic. Professor Hancock and his colleagues discovered that bacteria in abscesses are in a stress-triggered growth state. Using a synthetic peptide known as DJK-5, they were able to interfere with the bacteria’s stress response and heal abscesses in mice. The peptide was effective against two classes of bacteria, known as gram-positive and gram-negative bacteria, whose different cell wall structures make them susceptible to different antibiotics. Professor Hancock hopes to begin clinical trials on human infections within a year.

The study, “Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically,” appears online in EBioMedicine.

. New weapon for hard-to-treat bacterial infections. BCMJ, Vol. 58, No. 9, November, 2016, Page(s) 524 - News.

Above is the information needed to cite this article in your paper or presentation. The International Committee of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

About the ICMJE and citation styles

The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.

An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.

BCMJ standard citation style is a slight modification of the ICMJE/NLM style, as follows:

  • Only the first three authors are listed, followed by "et al."
  • There is no period after the journal name.
  • Page numbers are not abbreviated.

For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit

BCMJ Guidelines for Authors

Leave a Reply