Innovative coating for blood vessels reduces rejection of transplanted organs

Issue: BCMJ, vol. 63 , No. 8 , October 2021 , Pages 329 News

Researchers at UBC have found a way to reduce organ rejection following a transplant by using a polymer to coat blood vessels on the organ to be transplanted. The polymer substantially diminished rejection of transplants in mice when tested by collaborators at SFU and Northwestern University.

The polymer was developed by UBC pathology and laboratory medicine professor Dr Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and the Life Sciences Institute. The findings were published recently in Nature Biomedical Engineering (www.nature.com/articles/s41551-021-00777-y).

The discovery has the potential to eliminate the need for drugs on which transplant recipients rely to prevent their immune system from attacking a new organ as a foreign object. Dr Kizhakkedathu explained that blood vessels in organs are protected with a coating that suppresses the immune system’s reaction, but in the process of procuring organs for transplantation, the coating is damaged and no longer able to transmit the message. Dr Kizhakkedathu’s team synthesized a polymer and developed a chemical process for applying it to blood vessels. He worked with UBC chemistry professor Dr Stephen Withers and the study’s co-lead authors, PhD candidate Daniel Luo and recent chemistry PhD Dr Erika Siren.

The procedure has been applied only to blood vessels and kidneys in mice so far, but researchers are optimistic it could work equally well on lungs, hearts, and other organs. Clinical trials in humans could be several years away.

The research was supported by CIHR, NSERC, UBC, SFU, the Heart and Stroke Foundation of Canada, GlycoNet, and the Michael Smith Foundation for Health Research.

. Innovative coating for blood vessels reduces rejection of transplanted organs. BCMJ, Vol. 63, No. 8, October, 2021, Page(s) 329 - News.



Above is the information needed to cite this article in your paper or presentation. The International Committee of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

About the ICMJE and citation styles

The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.

An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.

BCMJ standard citation style is a slight modification of the ICMJE/NLM style, as follows:

  • Only the first three authors are listed, followed by "et al."
  • There is no period after the journal name.
  • Page numbers are not abbreviated.


For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org

BCMJ Guidelines for Authors

Leave a Reply