Two new studies, one of them involving Simon Fraser University researchers, have uncovered the first link between human colorectal cancer and a specific microorganism.
The studies, just published online in the journal Genome Research, found the bacterium Fusobacterium hundreds of times more prevalent in tumors than normal tissue in 99 colorectal cancer patients.
Fusobacterium is a known infectious agent that is rarely found in the contents of a normal gut. It has not previously been associated with cancer, and it has yet to be proven whether Fusobacterium infection causes or precedes colorectal tumors.
Researchers plan to further investigate the possibility that Fusobacterium could be a direct cause of colon cancer, and if so, by what mechanism. The same methodology can then be applied to look for correlations between infectious agents in other types of cancer. Some other cancers known to be caused by viruses or bacteria are cervical cancer (human papilloma virus) and liver cancer (hepatitis B and C virus).
Above is the information needed to cite this article in your paper or presentation. The International Committee
of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally
accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.
About the ICMJE and citation styles
The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.
An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.
BCMJ standard citation style is a slight modification of the ICMJE/NLM style, as follows:
- Only the first three authors are listed, followed by "et al."
- There is no period after the journal name.
- Page numbers are not abbreviated.
For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org