Scientists at the University of Waterloo have discovered that antidepressant medications can be used to treat Alzheimer disease. A study published in ACS Chemical Neuroscience, “Interactions of selective serotonin reuptake inhibitors with β‑amyloid,” found that selective serotonin uptake inhibitors (SSRI medication) can delay the development and growth of amyloid-beta proteins, which can clump together and form a plaque, contributing to disease symptoms. These plaques block cell-to-cell signals, resulting in delayed cognitive function. As the plaques grow, the brain’s ability to make connections and send and receive information becomes further impaired.
There are currently over 500 000 Canadians living with dementia, and no drugs on the market that offer a cure. Approximately 50% of people diagnosed with Alzheimer disease also have depression. Researchers believe knowledge from this study can one day inform how health care providers approach treatment in patients with both depression and Alzheimer disease, perhaps leading to the use of SSRIs as an early intervention for people who have a family history of dementia. The chemical structure of SSRIs presents a type of blueprint for how to develop a medication that will prevent amyloid-beta aggregation. The study is available at https://pubs.acs.org/doi/10.1021/acschemneuro.8b00160.
Above is the information needed to cite this article in your paper or presentation. The International Committee
of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally
accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.
About the ICMJE and citation styles
The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.
An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.
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For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org