July

Because of the rapid aging of the population and modern advan­ces in medicine, the likelihood of sudden death at a fairly young age is becoming more remote. The illness trajectory is changing to one of gradually increasing mental and functional frailty before death. 

Syphilis, caused by the bacterium Treponema pallidum sub spp pallidum, is an infection recognized since antiquity. It was first reported in Italy at the end of 15th century.[1] Infections may be sexually transmitted as well as spread from an infected mother to her fetus or through blood transfusions. 

Methadone is a synthetic opioid used for managing opioid dependence and as a second-line opioid analgesic. A dramatic increase in methadone use for pain has occurred over the last 10 years, with shared worldwide experience indicating that methadone has become one of the most important agents for treating opioid-nonresponsive pain in palliative care. 

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