Down syndrome, or trisomy 21, is a common congenital anomaly with an incidence rate of approximately 1 in 800 births across all ethnic groups. In dealing with the needs of patients and families facing this challenge, physicians will find the College library has a number of useful print and online resources. For example, Down syndrome results in an increased risk for several specific health conditions. The textbook Management of Genetic Syndromes (2005) provides a useful overview and may be borrowed from the library collection. Approximately 45% of children with Down syndrome will be born with a heart abnormality, which can be corrected before their preschool years. See Hurst’s the Heart (2008) and Congenital Heart Disease in Children and Adolescents in ACP PIER (2008) for details. Both of these texts are available for free online through the College library’s web site, www.cpsbc.ca/library.
Children with Down syndrome have a 14-fold increase in the overall rate of acute lymphoblastic leukemia and experience Alzheimer disease three to five times more frequently than the general population. For more, see Neoplastic Disease in the online text Current Diagnosis & Treatment Pediatrics (2009) or borrow Adams and Victor’s Principles of Neurology (2005).
For practice guidelines and authoritative patient information, try the College library’s search engine on the web site, or visit reliable sites like the Down Syndrome Research Foundation at www.dsrf.org. Remember that for high-quality clinical information to support patient care, the College library is only a phone call or e-mail away.
Above is the information needed to cite this article in your paper or presentation. The International Committee
of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally
accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.
About the ICMJE and citation styles
The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.
An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors.
BCMJ standard citation style is a slight modification of the ICMJE/NLM style, as follows:
- Only the first three authors are listed, followed by "et al."
- There is no period after the journal name.
- Page numbers are not abbreviated.
For more information on the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, visit www.icmje.org