Methadone is a synthetic opioid used for managing opioid dependence and as a second-line opioid analgesic. A dramatic increase in methadone use for pain has occurred over the last 10 years, with... Read More
Case data A 48-year-old female presented with a 2-day history of severe pain. Examination revealed redness and heat on her left thigh, with multiple new bullous formations and ulcerations. The... Read More
Background Heparin-induced thrombocytopenia (HIT) is an immune-mediated process that presents with a drop in platelet count related to proximate exposure to unfractionated or low molecular weight... Read More
In 2001 the New England Journal of Medicine published results of a randomized control trial by Rivers and colleagues of early goal-directed therapy (EGDT) that represented a significant advancement... Read More
In the early 1950s 80% of middle-aged men in the UK smoked and only 0.5% said they had never touched a cigarette. The Second World War was over and it was a time of social progress and general... Read More